Introduction to Focus Issue: Dynamical disease: A translational approach

The concept of Dynamical Diseases provides a framework to understand physiological control systems in pathological states due their operating an abnormal range parameters: this allows for the possibility return normal condition by redress values governing parameters. analogy with bifurcations dynamical opens mathematically modeling clinical conditions and investigating possible parameter changes that lead avoidance states. Since its introduction, has been applied number systems, most notably cardiac, hematological, neurological. A quarter century after inaugural meeting on diseases held Mont Tremblant, Québec [Bélair et al., Diseases: Mathematical Analysis Human Illness (American Institute Physics, Woodbury, NY, 1995)], Focus Issue offers opportunity reflect evolution field traditional areas as well contemporary data-based methods.